A pharmacokinetic - pharmacodynamic model for the effect of L - 1 arginine on endothelial function in patients with moderately severe 2 falciparum malaria
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چکیده
4 Janneke M. Brussee, Tsin W. Yeo, Daniel A. Lampah, Nicholas M. Anstey, Stephen B. 5 Duffull* 6 7 1. Otago Pharmacometrics Group, School of Pharmacy, University of Otago, Dunedin, New 8 Zealand 9 2. Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands 10 3. Global and Tropical Health Division, Menzies School of Health Research and Charles 11 Darwin University, Darwin, NT, Australia 12 4. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 13 5. Insitute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore 14 6. National Institute of Health Research and Development-Menzies School of Health 15 Research Malaria Research Program, Timika, Indonesia 16 7. Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia 17 18 * Corresponding author. Mailing address: Stephen B. Duffull, School of Pharmacy, University 19 of Otago, PO Box 56, Dunedin 9054, New Zealand, [email protected] 20 21 Running title: A PK-PD model of arginine in malaria 22
منابع مشابه
A Randomized Pilot Study of L-Arginine Infusion in Severe Falciparum Malaria: Preliminary Safety, Efficacy and Pharmacokinetics
BACKGROUND Decreased nitric oxide (NO) and hypoargininemia are associated with severe falciparum malaria and may contribute to severe disease. Intravenous L-arginine increases endothelial NO in moderately-severe malaria (MSM) without adverse effects. The safety, efficacy and pharmacokinetics of L-arginine or other agents to improve NO bioavailability in severe malaria have not been assessed. ...
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Severe falciparum malaria (SM) is associated with tissue ischemia related to cytoadherence of parasitized erythrocytes to microvascular endothelium and reduced levels of NO and its precursor, l-arginine. Endothelial function has not been characterized in SM but can be improved by l-arginine in cardiovascular disease. In an observational study in Indonesia, we measured endothelial function using...
متن کاملPharmacokinetics of L-arginine in adults with moderately severe malaria.
Severe malaria is associated with decreased nitric oxide (NO) production and low plasma concentrations of L-arginine, the substrate for NO synthase. Supplementation with L-arginine has the potential to improve NO bioavailability and outcomes. We developed a pharmacokinetic model for L-arginine in moderately severe malaria to explore the concentration-time profile and identify important covariat...
متن کاملSafety Profile of L-Arginine Infusion in Moderately Severe Falciparum Malaria
BACKGROUND L-arginine infusion improves endothelial function in malaria but its safety profile has not been described in detail. We assessed clinical symptoms, hemodynamic status and biochemical parameters before and after a single L-arginine infusion in adults with moderately severe malaria. METHODOLOGY AND FINDINGS In an ascending dose study, adjunctive intravenous L-arginine hydrochloride ...
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تاریخ انتشار 2015